Neuroprotective Effect of Magnesium Sulfate and
Dexamethasone on Intrauterine Ischemia in the Fetal
Rat Brain: Ultrastructural Evaluation
(Hasturk, Askin Esen.)
Bibliographical information (record 265268)
Neuroprotective Effect of Magnesium Sulfate and
Dexamethasone on Intrauterine Ischemia in the Fetal
Rat Brain: Ultrastructural Evaluation
- AIm: The aim of this study was to investigate the neuroprotective effect of magnesium sulfate and dexamethasone on oxidative damage in
intrauterine ischemia.
Ma terIal and Methods: In this study, 19-day pregnant rats were divided into five groups. Fetal brain ischemia was achieved in the ischemia/
reperfusion (I/R) group by bilaterally closing the utero-ovarian artery with aneurysm clips for 30 min and subsequently removing the aneurysm
clips for 60 min for reperfusion. Mg (600 mg/kg) and dexamethasone (0.25 mg/kg) were administered 20 min before the I/R insult. The lipid
peroxidation in the brain tissue was determined by the concentration of thiobarbituric acid reactive substances (TBARS). The mitochondrial
score was calculated after an evaluation with electron microscopy.
Results: Both the electron microscope and TBARS data showed a significant difference between the control and I/R groups. The Mg and
dexamethasone treatment groups exhibited significantly lower TBARS values compared to the IR group. Similarly, the mitochondrial scores in
the Mg and dexamethasone treatment groups were significantly lower than those in the I/R group.
ConclusIon: Result showed that magnesium sulfate and dexamethasone prevent lipid peroxidation and reduce mitochondrial injury thus
suggests neuroprotective effects in fetal rat brain in intrauterine ischemia-reperfusion (I/R) injury.
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