a Record control number WOS:000325465200008

a ISSN 1742-7835

a Original cataloging agency NEU GrandLibrary

a Language code of text/sound track or separate title eng

a Classification number QV18

b Item number .V58 2013

a Personal name Battal, Dilek,

h Medium Electronic Document

a Title In Vivo Genotoxicity Assessment of Sertraline by Using Alkaline Comet Assay and the Cytokinesis-Block Micronucleus Assay

c Statement of responsibility, etc Dilek Battal, Ayca Aktaş, Mehmet Ali Sungur, Ela Kadıoğlu, Ebru Derici Eker, Nefise Ozlen Şahin, Sahan Saygı .

b Name of publisher, distributor, etc Wıley Blackwell,

c Date of publication, distribution, etc 2013.

a Summary, etc Sertraline, a leading antidepressant in the selective serotonin reuptake inhibitor (SSRI) group of medicine, is the most frequently prescribed drug. In this study, the alkaline comet assay and the cytokinesis-block micronucleus (CBMN) assay were used to investigate genotoxicity potential of sertraline in the peripheral blood lymphocytes (PBLs) of acute and chronic sertraline-treated Wistar albino rats. Male Wistar albino rats (n=48) were administered low, medium and high doses of sertraline (10, 40, 80mg/kg) for acute and chronic treatment by employing the gavage method to investigate genotoxicity of the administered drug. The data (tail length, tail intensity and tail moment) were analysed and indicated that there was no statistically significant difference between sertraline-treated groups and the negative control group with respect to DNA damage (p>0.05). However, it was observed that acute sertraline administration had caused much more DNA damage in comparison with chronic treatment (p<0.05). According to the data obtained from the CBMN test, an increase in the micronucleus (MN) frequency was detected at chronic and high-dose acute sertraline treatment. Based on the outcome of comet assay, detection of statistically insignificant DNA damage may be due to the fact that sertraline did not cause damage on DNA. Also, increase in frequency of MN in chronic sertraline treatment suggests that chronic sertraline administration might influence some mechanisms of cell division. Therefore, dose adjustment in depressed patients seems significant as it may help prevent further prognosis of the diseases.

a Topical term or geographic name as entry element Near East University Article

a Topical term or geographic name as entry element Yakın Doğu Üniversitesi Makale

a Topical term or geographic name as entry element Pharmacology

a Topical term or geographic name as entry element Serotonın-Reuptake Inhıbıtors

a Topical term or geographic name as entry element Obsessive Compulsive Disorder

a Topical term or geographic name as entry element Antidepressants.

a Topical term or geographic name as entry element Pharmacokinetics

a Topical term or geographic name as entry element DNA damage.

g Relationship information Nov 2013, Vol.113 Issue:5, p.339-346

t Title Basıc & Clınıcal Pharmacology & Toxıcology

x International Standard Serial Number 17427835

u Uniform Resource Identifier http://library.neu.edu.tr:2048/login?url=http://dx.doi.org/10.1111/bcpt.12095